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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DUSP6
All Species:
26.36
Human Site:
S277
Identified Species:
64.44
UniProt:
Q16828
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16828
NP_001937.2
381
42320
S277
Q
F
F
P
E
A
I
S
F
I
D
E
A
R
G
Chimpanzee
Pan troglodytes
XP_526209
468
50775
S364
Q
F
F
P
E
A
I
S
F
I
D
E
A
R
S
Rhesus Macaque
Macaca mulatta
XP_001091142
368
40570
S264
Q
F
F
P
E
A
I
S
F
I
D
E
A
R
S
Dog
Lupus familis
XP_852241
381
42285
S277
Q
F
F
P
E
A
I
S
F
I
D
E
A
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBB1
381
42389
S277
Q
F
F
P
E
A
I
S
F
I
D
E
A
R
G
Rat
Rattus norvegicus
Q64346
381
42300
S277
Q
F
F
P
E
A
I
S
F
I
D
E
A
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506331
383
42666
T279
Q
F
F
P
E
A
I
T
F
I
D
E
A
R
S
Chicken
Gallus gallus
Q9PW71
375
41034
L276
A
T
I
C
L
A
Y
L
M
M
K
K
R
V
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
NP_001163824
383
42813
G277
Q
F
F
P
E
A
I
G
F
I
D
E
A
R
G
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794377
403
44845
F255
F
F
P
E
A
I
E
F
I
D
E
A
R
R
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.5
70
99.7
N.A.
98.1
98.6
N.A.
71
37.5
N.A.
N.A.
80.4
N.A.
N.A.
N.A.
45.4
Protein Similarity:
100
70.3
83.4
100
N.A.
98.9
99.4
N.A.
86.6
53.8
N.A.
N.A.
88.7
N.A.
N.A.
N.A.
59.3
P-Site Identity:
100
93.3
93.3
100
N.A.
100
100
N.A.
86.6
6.6
N.A.
N.A.
93.3
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
93.3
93.3
100
N.A.
100
100
N.A.
93.3
20
N.A.
N.A.
93.3
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
10
90
0
0
0
0
0
10
80
0
10
% A
% Cys:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
10
80
0
0
0
0
% D
% Glu:
0
0
0
10
80
0
10
0
0
0
10
80
0
0
0
% E
% Phe:
10
90
80
0
0
0
0
10
80
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
50
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
10
80
0
10
80
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
10
% K
% Leu:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
10
80
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
80
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
20
90
0
% R
% Ser:
0
0
0
0
0
0
0
60
0
0
0
0
0
0
30
% S
% Thr:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _